The Manifold Side Effects of Dexedrine

Dexedrine is one of the brand names for the drug dextroamphetamine that has quite a few uses in the medical industry. It is primarily used for the treatment of maladies such as attention deficit hyperactivity disorder, or ADHD, and narcolepsy, but physicians might also prescribe it for other issues as well. While it is a potent medicine that might also be used to enhance cognitive and athletic performance or for its recreational possibilities, it is important to understand the myriad of side effects that might manifest in a person who is tablets or capsules.

Physical Side Effects

The cardiovascular system of the body is one of the areas that is likely to be disturbed if physical side effects do manifest, but it should be noted that the incidence of these type of symptoms is diverse and depends much on age and the unique ability of a person’s body to handle the drug. If this system is affected, then there is likely to be either a reduction or increase in blood pressure (hypertension or hypotension). For this reason, blood pressure should be checked regularly and a physician notified if it reaches levels that are not ideal. An abnormally increased heart rate, or tachycardia, might also appear, and then there is also the possibility that the drug can cause a decreased blood flow to the body’s extremities in a condition known as Raynaud’s phenomenon.

Some sexual side effects of Dexedrine have occasionally been seen in those who are taking the medication. These are more likely to occur in men in the form of sexual dysfunction or perhaps prolonged and frequent erections. If this manifests in the form of impotence, then it might be accompanied by a decreased libido as well. Any of these should also be brought up with the prescribing doctor if they occur so that he or she might be able to provide a supplementary solution.

There can also be some other abdominal side effects of Dexedrine such as stomachache and pain along with an appetite loss that might result in overall weight loss and could be accompanied by nausea or similar discomfort. Finally, a number of others round out the possible physical side effects of the drug, and these include such things as a dry mouth, teeth grinding, blurred vision, nosebleed, excessive sweating, drug-induced congestion, tic, and a reduced seizure threshold. However, when the drug is taken at the normal levels that it is prescribed pharmaceutically, there is generally only rare occurrences of these with appetite and weight issues being the more common at around 10% or so of patients experiencing them.

Psychological Side Effects

There are also a number of possible psychological manifestations that might be noticed when taking the drug. These include things such as changes in the level of alertness, concentration, self-confidence, and initiative. This could be a positive thing at the normal levels that the drug is prescribed, and so they may actually be welcome for their positive effect on a person. But it may also have an opposite effect that is somewhat negative in nature such as increased apprehensibility and nervousness. It will vary depending on the person and their medical condition. Insomnia is somewhat common as well, with people having a decreased sense of fatigue that can cause them to experience restlessness and have trouble getting to sleep.

Overdose Possibilities

Since the aforementioned effects are usually not as likely to occur when a proper dose is taken as prescribed, it is only through overdoses that the majority of the more serious side effects of Dexedrine might occur. However, even then, it is still rarely fatal if the appropriate care is received in time to negate that possibility. An overdose can affect the body’s systems in different ways. The cardiovascular reactions might be increased or lowered blood pressure along with an abnormal heartbeat, but severe cases can result in cardiogenic shock, circulatory collapse, or bleeding in the brain.

The CNS (central nervous system) can result in abnormal reflexes, confusion, agitation, or tremors with the more severe cases leading to psychosis or excessive serotonergic (or adrenergic) activity. Muscle pain or breathing problems, body temperature issues, kidney failure, and body fluids with an excessive acidity are some others in the range of likelihoods when an overdose occurs. There are some others as well, and the spectrum is quite diverse so that no particular instance is likely to be realized in the same way as another person who exceeds the recommended dosage limits of the Dexedrine drug. In the worst cases, seizures, convulsions, or a coma might occur in a person before leading to a fatal outcome, but only approximately 4000 people die per year from such types of response, and many of these happen because of an addicted person intentionally taking more than prescribed or taking the drug when not ordered by a prescription. It is critical to follow the orders as directed and not take the medicine recreationally.

Drug Interactions Increasing Effects

There are a number of drugs that might increase the effects of Dexedrine, and this can subsequently lead to an increased level of side effects due to the interaction. Enzyme inhibitors are one such drug that should be taken with care if used in conjunction, and these include those for amphetamine metabolizers such as CYP2D6 and FMO3. MAOIs, or monoamine oxidase A inhibitors, might also be dangerous because of the fact that they also work in a similar manner as Dexedrine. Likewise, zinc supplementation treatment can reduce the amount required for an effective dose, and this might also lead to a more exaggerated response than would otherwise be seen in the patient.


In conclusion, Dexedrine is a mostly safe drug that has particular benefits when used instead of other amphetamine options such as Adderall that might have more severe side effects (especially in relation to the cardiovascular system). One just needs to keep a tab on their body’s response and discuss with the doctor accordingly if any of the mentioned effects are seen.