Xyrem is a depressant used for the central nervous system. It is designed to treat a loss of muscle strength due to cataplexy, and will reduce the sleepiness during the day for narcoleptic patients. The drug is commonly referred to as GHB, and is known for street abuse.

The active ingredient is sodium oxybate, and this can cause numerous Xyrem side effects requiring immediate medical attention. This includes:

  • Swelling or bloating of the lower legs, face, feet, hands and arms
  • Tingling in the feet or hands
  • A rapid weight gain
  • An unusual loss or gaining of weight
  • Anxiety
  • Chest discomfort or pain
  • Blurred vision
  • A decreasing amount of urine
  • A pounding, increased or fast heartbeat
  • Dizziness
  • Hoarseness
  • Headaches
  • Fever
  • Itching, rashes or hives
  • Swelling, stiffness or pain in the joints
  • Irritation
  • A pounding in the ears
  • Rattling or noisy breathing
  • Slow heartbeat
  • Redness in the skin
  • Tightness in the chest
  • Sweating
  • Difficulty swallowing or breathing
  • Difficulty breathing while at rest

Xyrem side effects become extremely dangerous in the occurrence of an overdose, and emergency medical help is required. These symptoms include:

  • Coma
  • Alternating periods of deep and shallow breathing
  • Not breathing
  • Bluish skin or lips
  • Loss of consciousness
  • Depression
  • Clumsiness
  • Agitation
  • Confusion
  • Combativeness
  • Drowsiness
  • Convulsions
  • Vomiting
  • Sleepiness
  • Shivering
  • The slowing of physical activity
  • The slowing of mental activity
  • The inability to hold urine or a bowel movement
  • An increase in sweating
  • Fainting
  • Dizziness or lightheadedness
  • Muscle weakness or aches
  • An unsteady walk
  • Shakiness
  • Unusual weakness or tiredness
  • Irregular or slow heartbeat
  • Feeble or weak pulse
  • Trembling
  • Trouble with coordination
  • Trouble with muscle control

There are additionally Xyrem side effects that do not require medical attention. These side effects often disappear as the body makes the required adjustments to the medication during the treatment. If these side effects occur, and become bothersome or continue to persist, the user should speak with their physician. The side effects include:

  • Burning
  • Itching
  • Numbness
  • A crawling sensation
  • A prickling sensation
  • A feeling of tingling or pins and needles
  • Confusion regarding the user’s location, their identity and the time
  • A drunk feeling
  • Diarrhea
  • A decrease in appetite
  • Not knowing where they are resulting in confusion
  • Irritability
  • Becoming forgetful
  • Pain in the stomach or upper abdominal area
  • Stiffness or pain in the muscles
  • Difficulty with moving

Xyrem has specific side effects on certain areas of the body. The effects and percentage of patients who have experienced these issues regarding the nervous system are listed below.

  • There is a ten to fifteen percent chance the user will experience headaches or dizziness
  • There is a ten percent chance the user will experience confusion, tremors, sleep paralysis, cataplexy paresthesia, hypoesthesia, a balance disorder, vertigo, dysgeusia, somnolence, sedation or a attention disturbance
  • There is a one percent chance the user will experience amnesia, myoclonus or restless leg syndrome
  • Although there is no available percentage, the user may experience convulsions or CNS depression

The psychiatric side effects of Xyrem include:

  • There is a one to ten percent chance the user will experience anxiety, depression, sleepwalking, parasomnia, irritability, disorientation, a confused state, abnormal dream patterns, nightmares, insomnia, sleep disorders or nervousness
  • There is a one percent chance the user will attempt suicide, hallucinate, paranoia, agitation, abnormal thinking or initial insomnia
  • Although there is no available percentage, the user may experience psychosis, begin thinking about suicide, or begin misusing or abusing the drug
  • There is a ten percent chance the user will experience peripheral edema, a drunk-like feeling, fatigue, pain, asthenia or fall

The gastrointestinal side effects of Xyrem include:

  • There is a ten to twenty percent chance the user will experience nausea, and an eleven percent chance of vomiting
  • There is a ten percent chance the user will experience abdominal pain, diarrhea or a dry mouth
  • There is a one percent chance the user will experience fecal incontinence

The musculoskeletal side effects of Xyrem include:

  • There is a ten percent chance the user will experience back pain, pain in the extremities, arthralgia or muscle spasms

The dermatologic side effects of Xyrem include:

  • There is a ten percent chance the user will experience rashes or hyperhidrosis
  • Although there is no available percentage, the user may experience urticaria

The respiratory side effects of Xyrem include:

  • There is a ten percent chance the user will experience snoring, dyspnea, nasopharyngitis, nasal congestion or sinusitis
  • Although there is no available percentage, the user may experience disoriented breathing while sleeping, respiratory depression or sleep apnea

The cardiovascular side effects of Xyrem include:

  • There is a ten percent chance the user will experience hypertension, palpitations, an increase in blood pressure
  • There is a one percent chance the user will experience hypersensitivity

The metabolic side effects of Xyrem include:

  • There is a ten percent chance the user will experience a decrease in appetite, anorexia, a decrease in weight or fluid retention

The Ocular side effects of Xyrem include:

  • There is a ten percent chance the user will experience blurred vision

The Renal side effects of Xyrem include:

  • There is a ten percent chance the user will experience urinary incontinence or Enuresis nocturna

The general side effects of Xyrem include:

  • Dizziness
  • Nausea
  • Vomiting
  • Enuresis
  • Somnolence
  • Tremors