An Analysis on Percocet Component Side Effects: Interactions, Severity, and Prevention

Percocet is a blend of oxycodone and acetaminophen. This drug is classified as an opioid. It is used in the treatment of moderate to severe pain. Percocet is available as a generic drug. It can only be obtained with a prescription from a doctor.

Most people have not experienced any problem while taking this medication. In genneral, the side effects of Percocet are not severe and are easy to treat.

The temporary effects of this drug are pain reduction and euphoria. Euphoria is caused by oxycodone, while acetaminophen relieves pain. These effects last 4-6 hours.

Common Percocet Side Effects

The side effects in the list below are similar to those of other opioids. They are usually minor.

Drug Interactions

  • Nausea/vomiting
  • Dryness in mouth
  • Poor apetite
  • Chest breathing
  • Hypotension
  • Orthostatic Hypotension
  • Pupillary constriction
  • Redness of skin

According to the FDA, Percocet should not be taken with alcohol. Driving and the operation of heavy machines should be avoided when taking Percocet. Percocet impairs your ability to think. It also slows your reaction time.

It is advisable to seek advice from a doctor if you take hypnotic pills or muscle relaxants.

 Percocet Side Effects (Psychological)

Uncommon Percocet Side Effects

  • Anxiety
  • Depression
  • Confusion
  • Insomnia
  • Hallucinations
  • Mood swings

Uncommon side effects are more serious than common side effects. You should seek medical attention right away if you experience any of the following symptoms:

  • Excessive sleepiness
  • Altered level of consciousness
  • Pain in the chest
  • Cyclic vomiting
  • Stools with clay color
  • Signs of allergies -Hives/rash -Swelling of throat, lips -Trouble breathing
  • Seizures
  • Irregular heart rhythm
  • Respiratory depression
  • Apnea

Swelling can make breathing difficult.

Percocet Side Effects of Overdose

Percocet tablets come in six strengths:2.5/325, 5/325, 7.5/325, 7.5/500, 10/325, and 10/650 mg. They should be swallowed whole so the oxyxcodone can be released slowly to avoid death.

Percocet has 650 mg of acetaminophen. Adults can take a maximum of four 1,000 mg doses per day. The side effects of Percocet overdose are the symptoms of oxycodone and acetaminophen overdose.



  • Blue skin
  • Extreme drowsiness
  • Slow heart beat
  • Coma
  • Excessive sweating
  • Death
  • Signs of liver damage -Severe pain in the abdomen -Dark urine -Yellow eyes or skin

Alcohol increases the risk of acetaminophen overdose. Liver failure can lead to death. If an acetaminophen pill is inhaled, the nasal passageways can become irritated.

Chronic Effects of Percocet

Since the 90s, the drug companies have marketed Percoret aggressively. Therefore, sufferers of chronic pain have increasingly used this drug.

The effects on the following list require medical monitoring.

  • Liver damage
  • Renal failure
  • Chronic constipation
  • Inability to urinate
  • Low testosterone (males only)
  • Dependence -Physical -Psychological

Effects of Long-Term Use of Percocet

Other Percocet Side Effects (Physical)

  • Edema in the body’s peripheral tissues
  • Osteoporosis
  • Sexual disorder
  • Immunosuppression
  • Ear Problems -Hearing loss -Ringing in the ears
  • Change in taste
  • Dehydration/thirst
  • Brain swelling
  • Electrolyte imbalance
  • Low/high blood sugar
  • Digestive System Problems -Diarrhea -Indigestion/heartburn -Pancreatitis -Bowel obstruction/ileus

Prevention of Side Effects

  • Blurry vision
  • Headaches

When Percocet is taken with food, the likelihood of nausea and vomiting is reduced. The FDA mandates that you do not take Percocet if you are allergic to it. Pregnant or breastfeeding women should not take Percocet. People with severe asthma should avoid this medication. Individuals that take other narcotic pain medications (i.e. methadone, morphine, Vicodin, Lortab) or narcotic cough medicines should not use Percocet.